Rh neutral or Golden Blood Type has no Rh antigen or protein in RBCs. It is the rarest group of blood in entire world. Around 50 of the entire population can have this group. Now the issue with so less availability, donation is extremely sparse and cumbersome to get.
So, they have to create a small web of connection within themselves to get the donor if required after undergoing blood type testing. As there is so limited access to the donors it’s regarded as most precious blood group named Golden Blood.
Unlike us, they don’t have any antigen. Also we have ABO system of the blood with further distinction of Rh-D cell factors. Here you will know to know a lot about this rarest blood type. So, let’s start.
Reasons to have Golden Blood Type in many persons
Genetic mutation (spontaneous gene change) results in this type of rare blood. It can be easily observed with RHAG gene mutation that codes Rh-centric glycoprotein. It needs to direct the Rh antigen to membrane of RBC. Often this condition associates to a condition known as hereditary stomatocytosis.
People having this condition experience mild, long-term haemolytic anaemia with increased breakdown rate of the RBC. This phenotype is also observed in many cases of anaemia-infected people. Find out a clinic using ‘blood group test near me’ to check your blood group.
Some conditions can put you at high risk if you have Golden Blood Type and they are:
- Consanguineous marriage (marriage within distant or near relative, brother-sister or cousins)
- Autosomal genes (unusual genes carrying disease traits of the families)
- Complete or partial change of specific genes like RHAG, RHCE and RHD
Associated complexities of Golden Blood Type
People having Golden Blood Type or Rh neutral may experience:
- Moderate to mild hemolytic anaemia after birth- It can cause rapid RBCs destructions and leads to low level of haemoglobin causing weariness and paleness. It happens due to the RBCs structural defects like
- Slit-like or mouth-like shape
- Less elasticity of RBCs
- Abnormal covering of red blood cells
- Because of absence of the Rh antigen heightened fragility
- Altered volume of the blood cell
- Challenges of blood transfusion- People having this blood type will experience issue in blood transfusion. If somehow, the blood of this person exposes to Rh antigen from the blood of another person then corresponding autoantibodies will form leading to severe reactions. So, every medical facility has set their special protocols for rapid response management.
- Incompatibility of Rh at the time of pregnancy- When a pregnant woman has Rh neutral and baby gets Rh positive blood type, the blood of the mother will sensitise by the positive blood of the baby. As a result the blood will generate protective proteins known as antibodies which generally target the future pregnancies leading to miscarriage or abortion too.
- Haemolytic crisis- Sepsis or similar infection can precipitate massive haemolysis which end up with other complexities including kidney failure and can be fatal.
Is it possible to donate Golden Blood Type?
Definitely, it is possible to donate the golden blood. Due to the antigen absence in RBC, the person having Rh neutral blood will be regarded as universal donor and blood is possible to donate to anybody having rare blood types including Rh systems.
It is outstanding to transfuse due to the lack of common antigens. Anybody who needs blood can transfuse with this one without the probability of any reaction. However, its rarity makes it tough to find out.
Also, neutral Rh is not good at all for people having this system. Otherwise, transfusion can lead to severe reaction at all. Prior to donate or undergo blood transfusion, you are recommended to undergo test. For that, look for a clinic using ‘blood tests London” and make an appointment.